Publications

Original Articles

  • Yang Y, Kim AH, Yamada T, Wu B, Bilimoria P, Ikeuchi Y, de la Iglesia N, Shen J, Bonni A. A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation. Science, In Press.
  • Mohideen F, Capili AD, Bilimoria PM, Yamada T, Bonni A, Lima CD. A molecular basis for phosphorylation-dependent SUMO conjugation by the E2 UBC9. Nat Struct Mol Biol 2009; 16:945-52.
  • Lehtinen MK, Tegelberg S, Schipper H, Su H, Zukor H, Manninen O, Kopra O, Joensuu T, Hakala P, Bonni A, Lehesjoki AE. Cystatin B deficiency sensitizes neurons to oxidative stress in progressive myoclonus epilepsy, EPM1. J Neurosci 2009; 29:5910-5.
  • Huynh MA, Stegmuller J, Litterman N, Bonni A. Regulation of Cdh1-APC function in axon growth by Cdh1 phosphorylation. J Neurosci 2009; 29: 4322-7.
  • Ikeuchi Y, Stegmuller J, Netherton S, Huynh MA, Masu M, Frank D, Bonni S, Bonni A. A SnoN-Ccd1 pathway promotes axonal morphogenesis in the mammalian brain. J Neurosci 2009; 29:4312-21.
  • Yuan Z, Lehtinen M, Merlo P, Villen J, Gygyi S, Bonni A. Regulation of neuronal cell death by MST1-FOXO1 signaling. J Biol Chem 2009; 284:11285-92.
  • Kim AH, Puram SV, Bilimoria PM, Ikeuchi Y, Keough S, Wong M, Rowitch D, Bonni A. A Centrosomal Cdc20-APC Pathway Controls Dendrite Morphogenesis in Postmitotic Neurons. Cell 2009; 136:322-36.
  • Oberdoerffer P, Michan S, McVay M, Mostoslavsky R, Vann J, Park SK, Hartlerode A, Stegmuller J, Hafner A, Loerch P, Wright SM, Mills KD, Bonni A, Yankner BA, Scully R, Prolla TA, Alt FW, Sinclair DA. SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell 2008; 135:907-18.
  • de la Iglesia N , Konopka G, Lim KL, Nutt C, Bromberg J, Frank D, Mischel P, Louis DN, Bonni A. Deregulation of a STAT3-IL8 signaling pathway promotes human glioblastoma cell proliferation and invasiveness. J Neurosci. 2008; 28:5870-8.
  • Yuan Z, Becker E, Merlo P, Yamada T, DiBacco S, Konishi Y, Schaefer E, Bonni A. Activation of FOXO1 by Cdk1 in cycling cells and postmitotic neurons. Science. 2008; 319:1665-8.
  • Sarker KP, Kataoka H, Chan A, Netherton SJ, Pot I, Huynh MA, Feng X, Bonni A, Riabowol K, Bonni S. ING2 as a novel mediator of TGFb-dependent responses in epithelial cells. J Biol Chem. 2008; 283:13269-79.
  • Stegmüller J, Huynh MA, Yuan Z, Konishi Y, Bonni A. TGFb-Smad2 signaling regulates the Cdh1-APC/SnoN pathway of axonal morphogenesis. J Neurosci. 2008 28:1961-9.
  • de la Iglesia N, Konopka G, Puram S, Bachoo R, Mingjian J, Levy D, DePinho R, Bonni A. Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway. Genes Dev. 2008; 22:449-62.
  • Shalizi A, Bilimoria P, Stegmuller J, Gaudilliere B, Yang Y, Shuai K, Bonni A. PIASx is a MEF2 SUMO E3 ligase that promotes postsynaptic dendritic morphogenesis. J Neurosci. 2007; 27:10037-46.
  • Ramos B, Gaudillière B, Bonni A, Gill G. Transcription factor Sp4 regulates dendritic patterning during cerebellar maturation. Proc Natl Acad Sci USA. 2007; 104:9882-7.
  • Iwase S, Lan F, Bayliss P, de la Torre-Ubieta L, Huarte M, Qi H, Whetstine J, Bonni A, Roberts TM, Shi Y.  The X-linked mental retardation gene SMXC/JARID1C defines a family of histone H3 lysine 4 demethylases. Cell. 2007; 128:1077-1088.
  • Cai B, Chang S, Becker EB, Bonni A, Xia Z. p38 MAP kinase mediates apoptosis through phosphorylation of Bimel at Ser65. J Biol Chem. 2006; 281:25215-22.
  • Lasorella A, Stegmüller J, Guardavaccaro D, Liu G, Rothschild G, de la Torre-Ubieta L, Pagano M, Bonni A, Iavarone A. Degradation of Id2 by the anaphase promoting complex couples control of cell cycle and axonal growth. Nature. 2006; 442: 471-474.
  • Lehtinen M, Yuan Z, Boag P, Yang Y, Villen J, Becker E, DiBacco S, de la Iglesia N, Gygi S, Blackwell TK, Bonni A.  A conserved MST-FOXO signaling pathway mediates oxidative stress responses and extends lifespan. Cell. 2006; 125: 987-1001.
  • Stegmüller J, Konishi Y, Huynh MA, Yuan Z, DiBacco S, Bonni A. Regulation of axonal morphogenesis by the Cdh1-APC target SnoN. Neuron. 2006; 50:389-400.
  • Becker E, Bonni A. Neural-specific activation of the mitochondrial apoptotic machinery. Neuron. 2006; 49:655-662.
  • Shalizi A, Gaudillière B, Yuan Z, Shirogane T, Stegmüller J, Ge Q, Tan Y, Schulman B, Harper JW, Bonni A. A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation. Science. 2006; 311:1012-1017.
  • Berndtsson M, Konishi Y, Bonni A, Hagg M, Shoshan M, Linder S, Havelka AM. Phosphorylation of BAD at Ser-128 during mitosis and paclitaxel-induced apoptosis. FEBS Lett. 2005; 579:3090-4.
  • Reginato MJ, Mills KR, Becker EBE, Lynch DK, Bonni A, Muthuswamy SK, Brugge JS. Bim regulation of lumen formation in cultured mammary epithelial acini is targeted by oncogenes. Mol Cell Biol. 2005; 25:4591-601.
  • Benedito A, Lehtinen M, Massol R, Kirchhausen T, Rao A, Bonni A. The transcription factor NFAT3 mediates neuronal survival. J Biol Chem. 2005; 280:2818-25.
  • Becker E, Howell J, Kodama Y, Barker PA, Bonni A. Characterization of the JNK-BimEL signaling pathway in neuronal apoptosis. J Neurosci. 2004; 24:8762-8770.
  • Konishi Y, Stegmüller J, Matsuda T, Bonni S, Bonni A. Cdh1-APC controls axonal growth and patterning in the mammalian brain. Science. 2004; 303:1026-30.
  • Gaudillière B, Konishi Y, de la Iglesia N, Yao G, Bonni A. A CaMKII-NeuroD signaling pathway specifies dendritic morphogenesis. Neuron. 2004; 41:229-41.
  • Bhakar AL, Howell JL, Paul CE, Salehi AH, Becker EBE, Said F, Bonni A, Barker PA. Apoptosis induced by p75NTR requires Jun Kinase-dependent phosphorylation of Bad. J Neurosci. 2003; 23:11373-11381.
  • Shalizi A, Lehtinen M, Gaudillière B, Donovan N, Han J, Konishi Y., Bonni A. Characterization of a neurotrophin signaling mechanism that mediates neuron survival in a temporally specific pattern. J Neurosci. 2003; 23:7326-7336.
  • Konishi Y, Bonni A. The E2F-Cdc2 cell cycle pathway specifically mediates activity deprivation-induced apoptosis of postmitotic neurons. J Neurosci. 2003; 23:1649-1658.
  • Gaudillière B, Shi Y, Bonni A. RNA interference reveals a requirement for MEF2A in activity-dependent neuronal survival. J Biol Chem. 2002; 277:46442-6.
  • Donovan N, Becker EB, Konishi Y, Bonni A. JNK phosphorylation and activation of BAD couples the stress-activated signaling pathway to the cell death machinery. J Biol Chem. 2002; 277:40944-40949.
  • Konishi Y, Lehtinen M, Donovan N, Bonni A.  Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery. Mol Cell. 2002; 9:1006-1015.

Review Articles and Book Chapters

  • de la Iglesia N, Puram S, Bonni A. STAT3 regulation of glioblastoma pathogenesis. Curr Mol Med. 2009 9:580-90.
  • Kim AH, Bonni A. Cdk1-FOXO1: a mitotic signal takes center stage in post-mitotic neurons. Cell Cycle 2008; 7:3819-22.
  • Bilimoria P, Bonni A. Cultures of cerebellar granule neurons. Cold Spring Harbor Laboratory Protocols. 2008; doi:10.1101/pdb.prot5107.
  • Lehtinen M, Bonni A. Demystifying MST kinases in cell death. Curr Mol Med. 2008; 8:313-8.
  • de la Torre-Ubieta, Bonni A. Combinatorial assembly of neurons: from chromatin to dendrites. Trends Cell Biology. 2008; 18:48-51.
  • Stegmüller J, Bonni A. Using RNAi in studies of cerebellar development. In Inhibitory RNAs in Neuroscience (Davidson B, Ed.) San Diego, CA, Society for Neuroscience, 2007.
  • Shalizi A, Bonni A. Not just for muscle anymore: activity and calcium regulation of MEF2-Dependent transcription in neuronal survival and differentiation. In Transcriptional Regulation by Neuronal Activity, Springer, New York, 2007.
  • Becker E, Bonni A. Pin1 in neuronal apoptosis. Cell Cycle. 2007; 6:1332-5.
  • Kim AH, Bonni A. Thinking within the D box: Initial identification of Cdh1-APC substrates in the nervous system. Mol Cell Neurosci. 2007; 34:281-287.
  • Lehtinen M, Bonni A. Modeling oxidative stress in the central nervous system. Curr Mol Med. 2006; 6:871-81.
  • Stegmüller J, Bonni A. Moving past proliferation: new roles for Cdh1-APC in postmitotic neurons. Trends Neurosci. 2005; 28:596-601.
  • Shalizi A, Bonni A. Brawn for brains: the role of the MEF2 proteins in the developing nervous system. Curr Top Dev Biol. 2005; 69:239-66.
  • Becker E, Bonni A. Beyond proliferation: cell cycle regulation of neuronal survival and differentiation. Semin Cell Dev Biol. 2005; 16:439-48.
  • Becker E, Bonni A. Cell cycle regulation of neuronal apoptosis in brain development and disease. Prog Neurobiol. 2004; 72:1-25.
  • Bonni A. STATs in the central nervous system, in The JAK-STAT Signaling Pathway. Kluwer Academic Publishers. London. 2003.
  • Bonni A.  Neurodegeneration: a non-apoptotic role for AIF in the brain. Curr Biol. 2003; 13: R19-R21.
  • Konopka G, Bonni A. Signaling mechanisms underlying gliomagenesis. Curr Mol Med. 2003; 3:73-84.